Head-up tilt

Patient specific modeling of head up tilt

Short-term cardiovascular responses to head-up tilt (HUT) involve complex cardiovascular regulation in order to maintain blood pressure at homoeostatic levels. This manuscript presents a patient-specific model that uses heart rate as an input to fit the dynamic changes in arterial blood pressure data during HUT. The model contains five compartments representing arteries and veins in the upper and lower body of the systemic circulation, as well as the left ventricle facilitating pumping of the heart.

Patient Specific Modeling of Head-Up Tilt.

Short-term cardiovascular responses to head-up tilt (HUT) involve complex cardiovascular regulation in order to maintain blood pressure at homoeostatic levels. This manuscript presents a patient-specific model that uses heart rate as an input to fit the dynamic changes in arterial blood pressure data during HUT. The model contains five compartments representing arteries and veins in the upper and lower body of the systemic circulation, as well as the left ventricle facilitating pumping of the heart.

Global sensitivity and identifiably analysis applied to a model predicting baroreflex regulation during head-up tilt

Mathematical modeling has long been used for prediction of biological phenomena, but practical use of mechanistic models for data analysis is not as common. One of the major obstacles is the lack of practical methods for model based data analysis. This study presents methods for predicting global sensitivities of model outcomes to model parameters and shows how global sensitivities can be used for predicting sets of globally identifiable parameters.

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