Frank-Starling law

Influence of metabolic dysfunction on cardiac mechanics in decompensated hypertrophy and heart failure

Alterations in energetic state of the myocardium are associated with decompensated heart failure in humans and in animal models. However, the functional consequences of the observed changes in energetic state on mechanical function are not known. The primary aim of the study was to quantify mechanical/energetic coupling in the heart and to determine if energetic dysfunction can contribute to mechanical failure.

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