Dahl SS rat; GFR; creatinine clearance; salt-sensitive hypertension

Progression of glomerular filtration rate reduction determined in conscious Dahl salt-sensitive rats

Sequential changes in glomerular filtration rate during development of hypertension in the conscious Dahl salt-sensitive rats were determined using a new method for measurement. Using a miniaturized device, disappearance curves of fluorescein isothiocyanate-sinistrin were measured by transcutaneous excitation and real-time detection of the emitted light through the skin.

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