Cell cycle and cell division

Effect of Regulatory Architecture on Broad versus Narrow Sense Heritability

Additive genetic variance (VA) and total genetic variance (VG) are core concepts in biomedical, evolutionary and production-biology genetics. What determines the large variation in reportedVA/VG ratios from line-cross experiments is not well understood. Here we report how the VA/VGratio, and thus the ratio between narrow and broad sense heritability (h2/H2), varies as a function of the regulatory architecture underlying genotype-to-phenotype (GP) maps.

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