Ellen is working with Rachel and Edith to collect data for left ventricular ejection fraction and the role of calcium in mitochondrial fuel selection. She will also be finishing data collection for researching the regulation of purine degradation pathways by mTORC1. Questions being answered by Ellen's work in the lab are:
- How are changes in AMP/ATP related to ejection fraction?
- How are metabolite pool concentration effected in heart failure?
- How does PDH effect fuel selection in mitochondria during high calcium and low calcium states?
Changes in AMP deaminase 1, 3 and Nt5c1a with respect to ejection fraction