Despite extensive study over the past six decades the coupling of chemical reaction and mechanical processes in muscle dynamics is not well understood. We lack a theoretical description of how chemical processes (metabolite binding, ATP hydrolysis) influence and are influenced by mechanical processes (deformation and force generation).
This package contains MATLAB codes for simulating in vivo cardiac energetics in normal and left ventricular hypertrophy (LVH) hearts as reported in “Wu F, Zhang J, & Beard DA (2009). Experimentally observed phenomena on cardiac energetics in heart failure emerge from simulations of cardiac metabolism. PNAS 106(17):7143-7148”. Please find a summary of the included codes and associated files in Description of the Codes_LVH.pdf.