The Virtual Physiological Rat Project aims to simulate the integrated cardiovascular function of the rat, and to build validated computer models that account for genetic variation across rat strains and physiological response to environment (i.e., diet). In addition, new strains of genetically engineered rat will be developed with the ultimate goal of using computer models to predict the physiological characteristics of not yet realized genetic combinations, derive those combinations in the lab, and then test the predictions.
Spotlight: Whole-Body Model of Long-Term Regulation of Arterial Pressure
A recent model developed by the VPR reveals long-term control of arterial blood pressure is primarily through the baroreflex arc and the renin-angiotensin system; and arterial stiffening provides a sufficient explanation for the etiology of primary hypertension associated with ageing. The model also provides the first consistent explanation of the physiological response to chronic stimulation of the baroreflex.
More information about the model can be found here.