Project Overview

The Virtual Physiological Rat Project is focused on the systems biology of cardiovascular disease—understanding how disease phenotypes apparent at the whole-organism scale emerge from molecular, cellular, tissue, organ, and organ-system interactions. Ongoing studies are particularly focused on the inexorable link between cardiac and peripheral physiology/pathophysiology in hypertensive heart disease, aiming to understanding how disease phenotypes apparent at the whole-organism scale emerge from molecular, cellular, tissue, organ, and organ-system interactions. Our overall scientific goals are to: (1.) use a systems approach to construct and test new hypotheses on cause-and-effect relationships in the etiology of hypertension and hypertensive heart disease; (2.) discover new strategies for managing, treating, and reversing disease mechanisms and improving/restoring intrinsic cardiac function, neurohumoral control of cardiac function, and physiological blood flow and pressure control; and (3.) use systems modeling to improve diagnosis and realize applications in precision medicine for cardiovascular disease.

Research Highlights

Dewan S, McCabe KJ, Regnier M, McCulloch AD, Lindert S
J. Phys. Chem. B, Article ASAP, 2016.
Belle A, Thiagarajan R, Soroushmehr SM, Navidi F, Beard DA, Najarian K
Biomed Res Int. 2015:370194, 2015. PMID: 26229957 PMCID: PMC4503556 
Tewari SG, Bugenhagen SM, Beard DA
J Molecular and Cellular Cardiology 96:11-25, 2015.
Tewari, SG
Tewari SG, Stowe DF, Camara AKS, Dash RK
J Physiol. 2014 May; 592(Pt9): 1917-30. PMCID: PMC4230769

Participating Labs

Auckland Bioengineering Institute
Cardiac Mechanics Research Group
NC State University
NTNU - Trondheim Norwegian University of Science and Technology
RGD - Rat Genome Database
Medical College of Wisconsin
Physiome Project
University of Wisconsin