The Virtual Physiological Rat Project is focused on the systems biology of cardiovascular disease—understanding how disease phenotypes apparent at the whole-organism scale emerge from molecular, cellular, tissue, organ, and organ-system interactions. Ongoing studies are particularly focused on the inexorable link between cardiac and peripheral physiology/pathophysiology in hypertensive heart disease, aiming to understanding how disease phenotypes apparent at the whole-organism scale emerge from molecular, cellular, tissue, organ, and organ-system interactions. Our overall scientific goals are to: (1.) use a systems approach to construct and test new hypotheses on cause-and-effect relationships in the etiology of hypertension and hypertensive heart disease; (2.) discover new strategies for managing, treating, and reversing disease mechanisms and improving/restoring intrinsic cardiac function, neurohumoral control of cardiac function, and physiological blood flow and pressure control; and (3.) use systems modeling to improve diagnosis and realize applications in precision medicine for cardiovascular disease.
Journal of Applied Physiology
Systems-level computational modeling demonstrates fuel selection switching in high capacity running and low capacity running rats
PLoS Comput Biol. 2018 Feb 23;14(2):e1005982
CEUR Workshop Proc. 2016 Aug;1747. pii: http://ceur-ws.org/Vol-1747/IT604_ICBO2016.pdf
Molecular Effects of cTnC DCM Mutations on Calcium Sensitivity and Myofilament Activation—An Integrated Multiscale Modeling Study
J. Phys. Chem. B, Article ASAP, 2016.
Influence of metabolic dysfunction on cardiac mechanics in decompensated hypertrophy and heart failure
J Molec. and Cell. Cardiology 94:152-175, 2016.
August 22, 2018
March 1, 2016
January 11, 2016
July 7, 2015
June 2, 2015